Drug synthesis reactions， especially asymmetric reactions， are the key components of modern pharmaceutical chemistry. Chemists have invested a lot in manpower and resources to identify various chemical reaction patterns in order to achieve efficient synthesis and asymmetric catalysis. The latest researches of quantum mechanical computing and machine learning algorithms in this field have proved the great potential of accurate virtual screening and learning the existing drug synthesis reaction data by computers. However， the existing methods only use few single-modal data， and can only use the common machine learning methods due to the limitation of not enough data. This hinders their universal application in a wider range of scenarios. Therefore， two screening models of drug synthesis reaction integrating multimodal data were proposed for virtual screening of reaction yield and enantioselectivity. At the same time， a 3D conformation descriptor based on Boltzmann distribution was also proposed to combine the 3D spatial information of molecules with quantum mechanical properties. These two multimodal data fusion models were trained and verified in two representative organic synthesis reactions （C-N cross coupling reaction and N， S-acetal formation）. The R²（R-squared） of the former is increased by more than 1 percentage point compared with those of the baseline methods in most data splitting， and the MAE（Mean Absolute Error） of the latter is decreased by more than 0.5 percentage points compared with those of the baseline methods in most data splitting. It can be seen that the models based on multimodal data fusion will bring good performance in different tasks of organic reaction screening.